AI Article Synopsis
- The study focused on creating macroporous 3D spongy scaffolds made of gelatin, alginate, and poly(vinyl alcohol) using a cryogelation technique, incorporating silver hydroxyapatite for enhanced properties.
- Various analytical methods, including FTIR, SEM, and XRD, were used to characterize the nanocomposite materials, assessing their porosity, water absorption, and mechanical strength.
- The scaffolds were evaluated for their effectiveness in bone tissue engineering by testing their antibacterial properties, cytotoxicity on preosteoblast cells, and the release of silver ions under different experimental conditions.
Article Abstract
In the present study macroporous three dimensional spongy scaffolds composed of gelatin, alginate, and poly (vinyl alcohol) were prepared by cryogelation technique and silver hydroxyapatite was reinforced into the 3 D matrix. The polymer nanocomposite materials were characterized by analytical techniques such as Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and x-ray diffraction (XRD) analysis. The nanocomposite scaffolds were studied for their porous nature, water sorption capacity, and mechanical behavior. The suitability of scaffolds for bone tissue engineering applications was judged by evaluating their antibacterial and cytotoxic nature against gram positive and gram negative bacteria, and MC3T3-E1 preosteoblast cells, respectively. The scaffolds were also studied for release of silver ions and the influence of various experimental conditions on the release profiles of silver ions was investigated.
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| http://dx.doi.org/10.1016/j.colsurfb.2019.01.064 | DOI Listing |
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