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VopX, a novel T3SS effector, modulates host actin dynamics.
mBio
January 2025
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.
Unlabelled: Pathogenic strains cause cholera using different mechanisms. O1 and O139 serogroup strains use the toxin-co-regulated pilus (TCP) and cholera toxin (CT) for intestinal colonization and to promote secretory diarrhea, while non-O1/non-O139 serogroup strains are typically non-toxigenic and use alternate virulence factors to cause a clinically similar disease. An O39 serogroup, TCP/CT-negative strain, named AM-19226, uses a type III secretion system (T3SS) to translocate more than 10 effector proteins into the host cell cytosol.
View Article and Find Full Text PDFWater pollution, cholera, and the role of probiotics: a comprehensive review in relation to public health in Bangladesh.
Front Microbiol
January 2025
Graduate School of Medicine, Science and Technology, Shinshu University, Nagano, Japan.
Cholera, a disease caused by , remains a pervasive public health threat, particularly in regions with inadequate water sanitation and hygiene infrastructure, such as Bangladesh. This review explores the complex interplay between water pollution and cholera transmission in Bangladesh, highlighting how contaminated water bodies serve as reservoirs for . A key focus is the potential role of probiotics as a novel intervention approach for cholera prevention and management.
View Article and Find Full Text PDFCholera in Nigeria: A review of outbreaks, trends, contributing factors, and public health responses.
Niger Med J
January 2025
Department of Medical Laboratory Services, Federal Medical Center, Yenagoa, Bayelsa State, Nigeria.
Cholera remains a significant public health challenge in Nigeria, with recurrent outbreaks exacerbated by inadequate water, sanitation, and hygiene (WASH) infrastructure, as well as conflict and displacement. This review examines cholera outbreaks in Nigeria from 2010 to 2024, analyzing epidemiological trends, contributing factors, and public health responses. Seasonal peaks during periods of heavy rainfall and flooding have consistently facilitated transmission, with Northern regions disproportionately affected due to poor infrastructure and ongoing conflicts.
View Article and Find Full Text PDFOptimized PCF architectures for THz detection of aquatic pathogens: Enhancing water quality monitoring.
PLoS One
January 2025
Department of Electrical and Electronic Engineering, Pabna University of Science and Technology, Pabna, Bangladesh.
Waterborne bacteria pose a serious hazard to human health, hence a precise detection method is required to identify them. A photonic crystal fiber sensor that takes into account the dangers of aquatic bacteria has been suggested, and its optical characteristics in the THz range have been quantitatively assessed. The PCF sensor was designed and examined as computed in Comsol Multiphysics, a program in which uses the method of "Finite Element Method" (FEM).
View Article and Find Full Text PDFGut Colonization of Zebrafish Larvae Induces a Dampened Sensorimotor Response.
Biomedicines
January 2025
Department of Biochemistry, Microbiology, and Immunology, Wayne State University, Detroit, MI 48201, USA.
Cholera is a diarrheal disease prevalent in populations without access to clean water. Cholera is caused by which colonizes the upper small intestine in humans once ingested. A growing number of studies suggest that the gut microbiome composition modulates animal behavior.
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