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Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Assessing delayed penicillin hypersensitivity using the PENFAST+ score.
Front Allergy
November 2023
Médecine Sorbonne Université, Service de dermatologie et d'allergologie, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Introduction: Approximately 10% of individuals report a suspected allergy to penicillin, but according to allergy work-ups, only 10%-15% of them are truly allergic. A clinical decision score, the PEN-FAST, was developed and validated to identify adults with low-risk penicillin allergy.
Objectives: The objective of this study was to improve the performance of the PEN-FAST score, particularly for those with delayed hypersensitivity (HS), by improving the negative predictive value.
Delayed eczematous skin reaction as an adverse drug reaction to immunoglobulin infusions: A case series.
Ann Dermatol Venereol
December 2022
Department of dermatology, Nantes University Hospital, 44000 Nantes, France.
Article Synopsis
- Pompholyx and eczematous skin reactions are known adverse effects of intravenous immunoglobulin (IVIg) infusions, but their detailed clinical characteristics and management remain under-researched.
- A study analyzing 27 cases of delayed skin reactions after IVIg infusions revealed that most patients were male, primarily had neurological conditions, and experienced the most common reaction, palmoplantar pompholyx, within an average of 11 days post-infusion.
- The findings indicated that severe reactions often required hospitalization, were more frequent in males receiving high doses, and relapses occurred frequently, especially after reintroduction of the same IVIg product.
Cutaneous Manifestations of COVID-19: An Experience From Oman.
Cureus
July 2021
Dermatology, Al-Nahdha Hospital, Muscat, OMN.
Objectives: To identify the cutaneous manifestations in COVID-19 disease in Oman.
Methods: The study was conducted in two phases with initial cross-sectional data collection with subsequent telemedical investigations of late skin manifestations including confirmed COVID-19 patients evaluated at Al-Nahdha Hospital and local health centers in Muscat from March 22 to June 2, 2020.
Results: The total number of patients included in the study was 374.
Spotted fever diagnosis: Experience from a South Indian center.
Pathog Glob Health
July 2021
Department of Pathology, Uniformed Services University of Health Sciences, Bethesda, MD, USA.
Spotted fever (SF) is an important treatable cause of acute febrile illness (AFI) with rash and has reemerged in India. A prospective AFI with rash study was undertaken at a South Indian hospital to correlate specific clinical findings with laboratory confirmation of spotted fever. During the study period (December 2017 to May 2019), 175 patients with fever and rash were suspected to have spotted fever.
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