Joel Bernstein, former Barry and Carol Kaye Professor of Applied Science at Ben-Gurion University, passed away on January 2, 2019. His legacy to the scientific community is a body of work on organic solid-state chemistry, chemical crystallography, polymorphism, hydrogen bonding, graph sets, structure-property relations, organic conducting materials, and pharmaceuticals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201900678 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exosomes Represent an Immune Suppressive T Cell Checkpoint in Human Chronic Inflammatory Microenvironments.
Immunol Invest
October 2020
Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
: T cells present in chronic inflammatory tissues such as nasal polyps (from chronic rhinosinusitis patients) have been demonstrated to be hypo-responsive to activation via the TCR, similar to tumor-specific T cells in multiple different human tumor microenvironments. While immunosuppressive exosomes have been known to contribute to the failure of the tumor-associated T cells to respond optimally to activation stimuli, it is not known whether they play a similar role in chronic inflammatory microenvironments. In the current study, we investigate whether exosomes derived from chronic inflammatory microenvironments contribute to the immune suppression of T cells.
View Article and Find Full Text PDFAcridine form IX.
Acta Crystallogr E Crystallogr Commun
April 2019
Department of Chemistry, Ben Gurion University of the Negev, Beer Sheva, 84105, Israel.
We report a new polymorph of acridine, CHN, denoted form IX, obtained as thin needles by slow evaporation of a toluene solution. The structure was solved and refined from powder X-ray data. The structures of five unsolvated forms were previously known, but this is only the second with one mol-ecule in the asymmetric unit.
View Article and Find Full Text PDFA new polymorph of ammonium succinate - serendipity in action.
Acta Crystallogr C Struct Chem
February 2019
Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Johannesburg, Gauteng, PO Wits 2050, South Africa.
Succinic acid has been known since 1546 and was first chemically identified in the mid-19th century. In an attempt to prepare a molecular salt of succinic acid with (S)-(-)-α-methylbenzylamine, we have obtained the second polymorph of the monoammonium salt of succinic acid, NH·CHO. The crystal structure determination proves the structure of the ionic compound and the intimate role of the ammonium ion in the structure, which is compared to the earlier described polymorph.
View Article and Find Full Text PDFCrystallographic education in the 21st century.
J Appl Crystallogr
December 2015
College of Science and Mathematics, California State University, San Marcos, Craven 6211, USA.
There are many methods that can be used to incorporate concepts of crystallography into the learning experiences of students, whether they are in elementary school, at university or part of the public at large. It is not always critical that those who teach crystallography have immediate access to diffraction equipment to be able to introduce the concepts of symmetry, packing or molecular structure in an age- and audience-appropriate manner. Crystallography can be used as a tool for teaching general chemistry concepts as well as general research techniques without ever having a student determine a crystal structure.
View Article and Find Full Text PDFFacts and fictions about polymorphism.
Chem Soc Rev
December 2015
Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, Basel, Switzerland.
We present new facts about polymorphism based on (i) crystallographic data from the Cambridge Structural Database (CSD, a database built over 50 years of community effort), (ii) 229 solid form screens conducted at Hoffmann-La Roche and Eli Lilly and Company over the course of 8+ and 15+ years respectively and (iii) a dataset of 446 polymorphic crystals with energies and properties computed with modern DFT-d methods. We found that molecular flexibility or size has no correlation with the ability of a compound to be polymorphic. Chiral molecules, however, were found to be less prone to polymorphism than their achiral counterparts and compounds able to hydrogen bond exhibit only a slightly higher propensity to polymorphism than those which do not.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!