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Backtrace:
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Backtrace:
File: /var/www/html/index.php
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Function: require_once
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355511 | PMC |
http://dx.doi.org/10.1016/j.jdcr.2018.10.011 | DOI Listing |
Drugs
December 2024
Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
Arimoclomol (MIPLYFFA™), an oral small molecule that crosses the blood brain barrier and is thought to upregulate CLEAR (Coordinated Lysosomal Expression and Regulation) network genes and improve lysosomal function, is being developed by Zevra Therapeutics Inc., for the treatment of neurological manifestations of Niemann-Pick disease type C (NPC). In September 2024, arimoclomol was approved for use in combination with miglustat for the treatment of neurological manifestations of NPC in adult and pediatric patients 2 years of age and older in the USA.
View Article and Find Full Text PDFDrugs
December 2024
Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
Xanomeline/trospium chloride (COBENFY™), formerly KarXT, is a first-in-class, oral, fixed-dose muscarinic agonist/antagonist combination being developed for use in schizophrenia and Alzheimer's disease psychosis. Xanomeline is thought to confer efficacy by acting as an agonist at M and M muscarinic acetylcholine receptors in the brain, and trospium chloride reduces the peripheral cholinergic adverse events associated with xanomeline. Xanomeline/trospium chloride received its first approval on 26 September 2024 in the USA for the treatment of schizophrenia in adults.
View Article and Find Full Text PDFBr J Nutr
December 2024
Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.
J Natl Cancer Inst
December 2024
Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States.
Oral Oncol
December 2024
Department of 'Organi di Senso', University "Sapienza", Viale Dell'Università, 33, Rome 00185, Italy.
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