Background: C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease.

Aim: The present study evaluates the association of CRP +1059 G/C polymorphism of the gene in 100 T2D cases and 100 healthy controls.

Methods: Present study was done by allele specific PCR method to study the gene polymorphism in study subjects.

Results: Study found that (+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher C allele frequency (0.16) was observed compared to controls (0.04). +1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters.

Conclusion: Study concluded that gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352458PMC
http://dx.doi.org/10.3889/oamjms.2019.014DOI Listing

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