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Evidence for a Role of the Long Non-Coding RNA ITGB2-AS1 in Eosinophil Differentiation and Functions.
Cells
November 2024
Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland.
Eosinophils, a type of granulocyte derived from myeloid precursors in the bone marrow, are distinguished by their cytoplasmic granules. They play crucial roles in immunoregulation, tissue homeostasis, and host defense, while also contributing to the pathogenesis of various inflammatory diseases. Although long non-coding RNAs (lncRNAs) are known to be involved in eosinophilic conditions, their specific expression and functions within eosinophils have not been thoroughly investigated, largely due to the reliance on tissue homogenates.
View Article and Find Full Text PDFDifferences in the direct effects of various type 2 cytokines on functions of blood eosinophils from healthy subjects.
Asia Pac Allergy
December 2024
Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan.
Article Synopsis
- Eosinophil inflammation in severe asthma often persists despite high-dose corticosteroid treatment, leading to the development of biologics targeting type 2 cytokines for corticosteroid-resistant cases.* -
- This study investigated the direct effects of type 2 cytokines (IL-4, IL-5, IL-13, TSLP) on eosinophils from healthy individuals, measuring indicators like adhesiveness and superoxide production.* -
- Results indicated that IL-5 significantly enhanced eosinophil functions, whereas IL-4, IL-13, and TSLP did not show such direct effects at clinical concentrations, implying limited eosinophil involvement in the action of certain biologics.*
Repercussions of Long-Term Naproxen Administration on LPS-Induced Periodontitis in Male Mice.
J Periodontal Res
November 2024
Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Aims: Chronic periodontitis is the sixth most prevalent disease worldwide and the leading cause of tooth loss in adults. With growing attention on the role of inflammatory and immune responses in its pathogenesis, there is an urgent need to evaluate host-modulatory agents. Non-steroidal anti-inflammatory drugs (NSAIDs) drugs play a crucial role in managing inflammatory conditions.
View Article and Find Full Text PDFMolecular characteristics of atopic dermatitis patients with clinical remission.
World Allergy Organ J
November 2024
Group of Clinical and Experimental Allergy (GACE), Hospital "Alma Mater de Antioquia", University of Antioquia, Medellín, Colombia.
Introduction: Atopic dermatitis (AD) is a frequent disease in infants with diverse clinical evolution. Although multiple studies have assessed inflammatory changes in chronic AD, little is known about the molecular transition from symptomatic stage to clinical remission without pharmacotherapy.
Objective: The aim of the study was to evaluate clinical and inflammatory factors and its relationship with AD clinical evolution.
Cucurbitacin IIb alleviates colitis via regulating gut microbial composition and metabolites.
Heliyon
September 2024
Medical Research Center, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410004, China.
Article Synopsis
- * The compound mitigates symptoms like weight loss and inflammation markers by lowering pro-inflammatory cytokines and improving intestinal structure, while also affecting gut bacteria and metabolites.
- * Notably, the use of antibiotics reduces the effectiveness of cucurbitacin IIb, but fecal transplants from treated mice can replicate its beneficial effects on colitis.
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