AI Article Synopsis
- The intestinal microbiome is crucial for human health, impacting immune response, metabolism, and disease processes.
- Fecal microbiota transplantation (FMT) is effectively used to treat recurrent Clostridium difficile infections and shows promise for disorders linked to microbial imbalances.
- Current research on FMT for hematologic conditions is scarce, but there are reported improvements in immune thrombocytopenic purpura, CDI, and aGVHD after hematopoietic stem cell transplantation.
Article Abstract
Intestinal microbiome closely relates with human health and disease, which plays a critical role in the immune response, homeostasis, drug metabolism and tumorigenesis. Imbalances in the composition and function of these intestinal microbes associate with diseases. Fecal microbiota transplantation (FMT) is an established successful treatment modality for recurrent Clostridium difficile infection (CDI). The safety profile and potential therapeutic advantages of FMT for diseases associated with dysbiosis and immune dysfunction have led to many publications, mainly case series. The literature on the use of FMT for hematologic diseases is very limited, however, immune thrombocytopenic purpura（ITP）, CDI and aGVHD after HSCT were reported to be improved by FMT. The aim of this review is to briefly summarize the research current state, procedures and clinical application of FMT.
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| http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.051 | DOI Listing |
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