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The adenosine analogs, 9-beta-D-xylofuranosyladenine (XA) and 3'-deoxyadenosine (cordycepin) were tested for their ability to interfer with S-adenosyl-L-methionine (SAM) formation in L1210 cells in vitro. XA inhibited the incorporation of [3H]methionine into SAM in a mixed-competitive manner, while cordycepin was not inhibitory. The adenosine deaminase inhibitor, 2-deoxy-coformycin produced a marked potentiation of the inhibitory effect of XA on Sam synthesis, but did not affect the inactivity of cordycepin.
View Article and Find Full Text PDFCordycepin and xylosyladenine: inhibitors of methylation of nuclear RNA.
Biochem Biophys Res Commun
March 1978
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