AI Article Synopsis
- The rise in the use of immune checkpoint inhibitors has led to an increase in immune-related side effects, including type 1 diabetes.
- An 81-year-old woman developed fulminant type 1 diabetes after receiving avelumab, which was recently approved for treating metastatic Merkel cell carcinoma.
- This case highlights the importance of closely monitoring blood sugar levels in patients undergoing treatment with avelumab and similar immune checkpoint inhibitors.
Article Abstract
With the expansive use of immune checkpoint inhibitors, the frequency of immune-related adverse events, including autoimmune type 1 diabetes, has been exponentially increased. The anti-programmed death-ligand 1 antibody, avelumab, has recently been approved for metastatic Merkel cell carcinoma therapy. Here, we report a patient that developed fulminant type 1 diabetes during avelumab treatment. An 81-year-old woman with no history of diabetes received avelumab for metastatic Merkel cell carcinoma. Elevated plasma glucose level (483 mg/dL), hemoglobin A1c level (7.5%) and ketosis were observed after 10 courses of avelumab without any symptoms related to hyperglycemia. As the laboratory tests showed insulin depletion, we diagnosed her with fulminant type 1 diabetes induced by avelumab. This is the first reported case of avelumab-induced type 1 diabetes, illustrating the necessity for close monitoring of glycemic control during avelumab therapy, as well as other immune checkpoint inhibitors.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717815 | PMC |
| http://dx.doi.org/10.1111/jdi.13022 | DOI Listing |
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