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Article Abstract
Background: There are currently no data predicting chemosensitivity of induction chemotherapy (ICT) for hypopharyngeal squamous cell carcinomas (SCC).
Methods: Associations between immune cells and overall response (OR) to ICT and changes in immune cells during ICT were observed in 40 patients with hypopharyngeal SCC undergoing ICT.
Results: CD4 and CD8 T-cell and regulatory T-cell (Treg) frequencies reached diagnostic accuracy for OR to ICT. OR rate was significantly higher in CD4 -high T cell, CD8 -high T cell, and low Treg groups. A transient reduction in Tregs and increases in Tregs in the non-OR and OR groups were observed during the course of ICT. Conversely, increases in CD8 T cells and reductions in CD8 T cells in the non-OR and OR groups were observed.
Conclusion: High CD4 T-cell, high CD8 T-cell, and low Treg frequencies can be predictors for high efficacy of ICT in patients with hypopharyngeal SCC.
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| http://dx.doi.org/10.1002/hed.25699 | DOI Listing |
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