[State of bone in children living in different conditions of environment].

Objective: Introduction: Environmental pollution, deficiency of fluorine and iodine significantly affect the state of dental health of children and the structural and functional status of the bone system. The aim: Therefore, the task of our study was to establish a connection between the structural and functional state of bone tissue and dental ankles with anthropogenic and geochemical factors in the environment.

Patients And Methods: Materials and methods: In order to achieve the goal of the study, we examined 496 children aged 6-15 years living in areas with different ecological loads. The structural and functional status of bone tissue in children was determined using an Achilles + ultrasonic densitometer (Lunar Corp., Madison, WI) on the hemisphere, which is dominated by trabecular bone tissue. The content of calcium in serum was determined using the arsenase-III method, inorganic phosphorus - by ultraviolet detection of the phosphomolybdate complex. As a bone marrow marker in blood serum, the activity levels of alkaline phosphatase, spectrophotometric, and osteocalcin, were measured using the N-MID Osteocalcin (Nordic Bioscience Diagnostics A / S, Canada) by U.S. Method.

Results: Results: The results of the study revealed that anthropogenic environmental factors lead to a decrease in the mineral density of bone tissue, which was more pronounced in children 6-11 years old with ARCHA plain region (IMCT = 69.14 ± 0.82&) than their peers in the foothills (IMCT = 71.63 ± 0.80&) and mountainous (IMCT = 73.62 ± 0.92&) regions, regardless of age, which was confirmed by the prevalence of recent normal values of bone mineral density and a decrease in the proportion of destructive forms of BMD (osteopenia, osteoporosis) It has been established that children living in ecologically unfavorable regions are not only suffering from mineralization of bone tissue, but also biochemical, molecular genetic and membrane-disruptive processes (especially those with CSF).

Conclusion: Conclusions: Prospects for further research are the development of a complex of therapeutic and prophylactic measures to increase the mineral density of bone tissue.