Accuracy and precision of electrical permittivity mapping at 3T: the impact of three mapping techniques.

Purpose: To investigate the sequence-specific impact of amplitude mapping on the accuracy and precision of permittivity reconstruction at 3T in the pelvic region.

Methods: maps obtained with actual flip angle imaging (AFI), Bloch-Siegert (BS), and dual refocusing echo acquisition mode (DREAM) sequences, set to a clinically feasible scan time of 5 minutes, were compared in terms of accuracy and precision with electromagnetic and Bloch simulations and MR measurements. Permittivity maps were reconstructed based on these maps with Helmholtz-based electrical properties tomography. Accuracy and precision in permittivity were assessed. A 2-compartment phantom with properties and size similar to the human pelvis was used for both simulations and measurements. Measurements were also performed on a female volunteer's pelvis.

Results: Accuracy was evaluated with noiseless simulations on the phantom. The maximum bias relative to the true distribution was 1% for AFI and BS and 6% to 15% for DREAM. This caused an average permittivity bias relative to the true permittivity of 7% to 20% for AFI and BS and 12% to 35% for DREAM. Precision was assessed in MR experiments. The lowest standard deviation in permittivity, found in the phantom for BS, measured 22.4 relative units and corresponded to a standard deviation in of 0.2% of the average value. As regards precision, in vivo and phantom measurements were comparable.

Conclusions: Our simulation framework quantitatively predicts the different impact of mapping techniques on permittivity reconstruction and shows high sensitivity of permittivity reconstructions to sequence-specific bias and noise perturbation in the map. These findings are supported by the experimental results.