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[Alfred Kirstein-A pioneer of direct laryngoscopy].
Anaesthesiologie
December 2024
, Feldhoopstücken 36-40, 22529, Hamburg, Deutschland.
On 23 April 1895, the Berlin ENT medical specialist Alfred Kirstein performed the first direct examination of the larynx using a Casper esophagoscope equipped with electric lighting, which he called an "autoscope". The examination of the larynx, which had previously only been possible indirectly using mirror systems, was named by him "autoscopy". The development of the device enabled a more precise observation than before and laryngeal or tracheal foreign bodies could be removed better and more easily.
View Article and Find Full Text PDFMirror Ear: A Rare Case of Polyotia.
Kathmandu Univ Med J (KUMJ)
September 2024
Department of Pathology, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
Article Synopsis
- Polyotia, also known as mirror ear or accessory ear, is a rare external ear anomaly where an extra auricle closely resembles a real ear rather than just a small skin tag, with less than 30 cases reported so far.
- Two cases of polyotia were successfully treated at Dhulikhel Hospital, involving an 8-year-old and a 14-year-old boy, each with a large accessory auricle on different sides, that mirrored the main auricle.
- The surgical correction involved carefully removing the extra cartilage and skin, reshaping it to fill gaps, and reconstructing the tragus using a graft.
Outpatient partial parotidectomies are feasible in a well-selected population: a French experience.
Eur Arch Otorhinolaryngol
September 2024
Department of ENT - Head and Neck Surgery, University Hospital of Nîmes CHU, Nîmes, France.
Purpose: This study aimed to evaluate the feasibility, safety, and patient satisfaction of outpatient partial parotidectomies in a French university hospital, addressing the lack of national data on such procedures amidst a push for increased ambulatory surgeries.
Methods: A prospective cohort study was conducted, involving patients undergoing partial parotidectomy for non-malignant tumors from March 2021 to May 2023. Inclusion was based on surgical, medical, and social criteria.
Backbone-Determined Antiarrhythmic Structure-Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product.
J Med Chem
July 2024
Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
Cyclic oligomeric depsipeptides (COD) are a structural class within naturally occurring compounds with a wide range of biological activity. Verticilide is a COD (24-membered ring) that was identified by its inhibition of insect ryanodine receptor (RyR). We have since found that the enantiomer of verticilide (-verticilide, ) is a potent inhibitor of mammalian RyR2, a cardiac calcium channel, and therefore a potential antiarrhythmic agent.
View Article and Find Full Text PDFPost-COVID-19 Hyposmia Does Not Exhibit Main Neurodegeneration Markers in the Olfactory Pathway.
Mol Neurobiol
November 2024
Department of Biochemistry and Cell Biology, National Research Council of Italy, Rome, Italy.
The biological substrate of persistent post-COVID-19 hyposmia is still unclear. However, as many neurodegenerative diseases present with smell impairment at onset, it may theoretically reflect degeneration within the central olfactory circuits. However, no data still exist regarding the post-COVID-19 patients.
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