Introduction: One of the risk factors for cardiovascular disease is inflammation. The role that it plays in the pathogenesis of cardiovascular disease remains a topic of ongoing research. The aim of this study was to identify the appearance and distribution of inflammatory markers, interleukins 1α (Il-1α) and 10 (Il-10) and β defensins 2 (βD2), 3 (βD3), and 4 (βD4), in the right atrial tissue from different acquired heart diseases.
Methods: During cardiac surgery, right atrial tissue fragments were taken from 23 patients with acquired heart diseases. Tissue fragments were stained for immunohistochemical detection of Il-1α, Il-10, βD2, βD3 and βD4.
Results: Few to a moderate number of Il-1α-positive cells and a moderate to great number of Il-10-, βD2- and βD3-positive cells were detected in right atrial tissue. There was a positive correlation between the level of CRP and the number of βD3-positive cardiomyocytes (r(s) 0.463; p .026). We found a negative correlation between the left ventricular ejection fraction and the number of βD2-positive cells in connective tissue (r(s) -0.524; p 0.012).
Conclusions: The rich expression of antimicrobial peptides and its association with CRP support the idea that an inflammatory process is involved in the pathogenesis of acquired heart diseases. The worst preoperative condition is associated with increased antimicrobial peptide expression in the right atrial cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.14670/HH-18-091 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
MicroRNA as a Potential Diagnostic and Prognostic Biomarker in Diffuse Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis.
Cancer Rep (Hoboken)
January 2025
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Background: Recently, microRNAs (miRNAs) have been applied as biomarkers for diffuse large B-cell lymphoma (DLBCL) patients. Early diagnosis and management of DLBCL can improve patient survival and prognosis.
Aims: This systematic review and meta-analysis aimed to evaluate the diagnostic and prognostic accuracy of miRNA biomarkers in DLBCL patients.
Role of Intraoperative Left Ventricular Global Longitudinal Strain in Hemodynamic and Cognitive Outcomes in On-Pump Coronary Artery Bypass Surgery: A Prospective Observational Study.
Ann Card Anaesth
January 2025
Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil.
Background: The role of left ventricular global longitudinal strain (LVGLS) in coronary artery bypass grafting (CABG) and outcomes such as low cardiac output syndrome (LCOS) is not well established. The authors investigated the relationship between LVGLS before and after induction of anesthesia, their differences, and their relationship with LCOS and other outcomes.
Methodology: A prospective observational study was conducted in a public/private hospital with 50 adult patients scheduled for on-pump CABG with normal left ventricular ejection fraction (LVEF).
Pain detection using biometric information acquired by a wristwatch wearable device: a pilot study of spontaneous menstrual pain in healthy females.
BMC Res Notes
January 2025
Department of Palliative Nursing, Tohoku University Graduate School of Medicine, 2- 1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Objective: Pain is subjective, and self-reporting pain might be challenging. Studies conducted to detect pain using biological signals and real-time self-reports pain are limited. We evaluated the feasibility of collecting pain data on healthy females' menstrual pain and conducted preliminary analysis.
View Article and Find Full Text PDFPractice patterns for acquiring neuroimaging after pediatric in-hospital cardiac arrest.
Resuscitation
January 2025
Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Aims: To determine which patient and cardiac arrest factors were associated with obtaining neuroimaging after in-hospital cardiac arrest, and among those patients who had neuroimaging, factors associated with which neuroimaging modality was obtained.
Methods: Retrospective cohort study of patients who survived in-hospital cardiac arrest (IHCA) and were enrolled in the ICU-RESUS trial (NCT02837497).
Results: We tabulated ultrasound (US), CT, and MRI frequency within 7 days following IHCA and identified patient and cardiac arrest factors associated with neuroimaging modalities utilized.
RNA-Seq transcriptomic landscape profiling of spontaneously hypertensive rats in youth treated with a ARNI versus ARB.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, No. 74, Linjiang Road, Chongqing, 400010, China.
Angiotensin receptor-neprilysin inhibitor (ARNI) and angiotensin II receptor blockers (ARB) are antihypertension medications that improve cardiac remodeling and protect the heart. However, at the early stage of hypertension, it is still unclear how these two drugs affect the transcriptomic profile of multiple organs in hypertensive rats and the transcriptomic differences between them. We performed RNA sequencing to define the RNA expressing profiles of the eight tissues (atrium, ventricle, aorta, kidney, brain, lung, white fat, and brown fat) in spontaneously hypertensive rats (SHRs) and SHRs treated with ARNI or ARB.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!