AI Article Synopsis
- Two new compounds and one new natural product were identified and isolated from a specific type of fungus (sp. SYPF7381), along with six known compounds.
- The structures of these compounds were determined using advanced techniques like spectroscopic analysis and optical rotation, with some configurations confirmed via electronic circular dichroism (ECD) calculations.
- The research also explored the anti-inflammatory effects of all compounds on RAW 264.7 cells, focusing on the relationship between their structures and their anti-inflammatory activities based on experiments and docking studies.
Article Abstract
Two new compounds, (7 2 5)-3,5,7-trimethyl-2,5-octadienedioic-8-methyl ester () and neovasipyridone G (), together with a new natural product compound (725)-3,5,7-trimethyl-2,5-octadienedioic acid (), and six known compounds () were isolated from sp. SYPF7381. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of compounds and were determined by optical rotation. The absolute configuration of compound was determined by means of electronic circular dichroism (ECD) calculation. In addition, the anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing LPS-induced NO production. Furthermore, the structure-antiinflammation activity relationships for these isolated compounds were summarized based on the experimental as well as the docking results.
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| http://dx.doi.org/10.1080/14786419.2019.1569662 | DOI Listing |
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