Background: Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging.
Methods: White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients ( = 15) and matched controls ( = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Volumes of 12 thalamic nuclei were measured using an automatic segmentation pipeline specifically developed for WMn-MPRAGE.
Results: WMn-MPRAGE showed more thalamic MS lesions ( = 35 in 9 out of 15 patients) than MP-FLAIR ( = 25) and standard T1 ( = 23), which was associated with significant improvement of CNR ( < 0.0001). MS patients had whole thalamus atrophy ( = 0.003) with lower volumes found for the anteroventral ( < 0.001), the pulvinar ( < 0.0001), and the habenular ( = 0.004) nuclei.
Conclusion: WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy.
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| http://dx.doi.org/10.1177/1352458519828297 | DOI Listing |
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