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Detection of enoxaparin and argatroban by use of the novel viscoelastic coagulometer ClotPro.
Sci Rep
November 2024
Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Division of General Anaesthesia and Intensive Care Medicine, Medical University of Vienna, Währinger Gürtel 18-20, Wien, Vienna, 1090, Austria.
Article Synopsis
- The study investigates point-of-care diagnostic tests for monitoring the anticoagulants enoxaparin and argatroban in critically ill patients who face risks of thrombosis and bleeding.
- Blood samples from twelve healthy volunteers were used to evaluate the performance of the ClotPro viscoelastic coagulometer alongside traditional coagulation tests.
- Results indicated that the RVV test for enoxaparin is not reliable, while the ECA test shows strong correlation and may be a better option for accurately detecting argatroban levels.
Hematology products from snake venoms.
Thromb Res
January 2025
Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA. Electronic address:
Venoms have primarily been used to prepare antivenoms for the treatment of snake bites, but they have constituents that might serve other medical needs. These include metalloproteinases, serine proteases, phospholipases, and C-type lectin-like proteins. Some of the products that have been prepared from venoms are procoagulants employed as topical hemostatics, and either applied directly to bleeding wounds or used as adjuncts to surgical procedures to assist in controlling blood loss.
View Article and Find Full Text PDFThe establishment of reference intervals for the ClotPro thromboelastometry device in healthy dogs.
J Vet Emerg Crit Care (San Antonio)
December 2024
School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.
Objective: To establish reference intervals using a new point-of-care thromboelastometry device in dogs for the extrinsically activated test (EX-test), intrinsically activated test (IN-test), fibrin polymerization test (FIB-test), ecarin test (ECA-test), and tissue plasminogen activator test (TPA-test) and to investigate the effects of storage time on the results.
Design: Prospective clinical study in 2022.
Setting: University teaching hospital.
Monitoring the efficiency of reversal on anti-Xa direct oral anticoagulants using point-of-care viscoelastic testing.
Thromb J
October 2024
Division of Hematology and Hemostasis, Department of Medicine I, Thrombosis Research, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Article Synopsis
- Direct oral anticoagulants (DOAC) can cause severe bleeding that is hard to detect using standard tests, leading to urgent recognition and management once a patient is admitted to the hospital.
- New point-of-care viscoelastic testing (VET) methods like the Russell viper venom factor V test allow for quicker and more accurate measurement of DOAC levels, which is crucial during severe bleeding emergencies.
- The study demonstrates the effectiveness of using RVV-clotting time to assess the reversal of direct FXa inhibitors after administering andexanet alfa, highlighting the need for reliable tests to monitor treatment outcomes in these critical situations.
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