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Topography-guided, patterned, customized corneal crosslinking for non-invasive astigmatism correction.
Eye (Lond)
January 2025
Bio-manufacturing Engineering Laboratory, International Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China.
Objectives: To propose and evaluate a novel, non-invasive approach for enduring corneal astigmatism correction based on topography-guided, patterned, customized riboflavin-ultraviolet A corneal collagen crosslinking (CXL).
Methods: Astigmatism was modelled on both eyes of rabbits. A randomly selected eye of each rabbit was treated by the proposed CXL procedure with another eye as control.
Delayed spontaneous resolution of a double anterior chamber following deep anterior lamellar keratoplasty (DALK).
BMC Ophthalmol
December 2024
Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: This study reports a rare case of delayed spontaneous resolution of double anterior chambers (AC) resulting from non-rhegmatogenous Descemet membrane detachment (DMD) after deep anterior lamellar keratoplasty (DALK). Currently, management guidelines for this condition have not been established.
Case Presentation: A 65-year-old woman with lattice corneal dystrophy underwent uncomplicated DALK, during which an unrecognized type 2 big bubble was present.
Unilateral lattice corneal dystrophy with c.1501C>A (p.P501T) and c.1733T>C (p.L578P) variants in the transforming growth factor-beta induced gene: a case report.
Ophthalmic Genet
December 2024
Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
Background: Corneal dystrophies (CDs) significantly affect quality of life. However, their progression and characteristics remain unclear. This study aimed to report a case of a unilateral variant of lattice corneal dystrophy (LCD) with c.
View Article and Find Full Text PDFIn Vivo Confocal Microscopy in Avellino Corneal Dystrophy.
Cureus
August 2024
Department of Ophthalmology, Erasmus Hospital, Brussels, BEL.
Corneal dystrophies are a group of rare genetic eye disorders characterized by the accumulation of abnormal material in different layers of the cornea, potentially leading to vision impairment. In vivo confocal microscopy (IVCM) is an emerging non-invasive imaging and diagnostic tool that helps study the ocular surface microstructure. This case report examines the clinical characteristics of Avellino corneal dystrophy in a young patient through the use of slit lamp examination, IVCM, and optical coherence tomography (OCT) in order to assess the effectiveness of these non-invasive tests as diagnostic tools.
View Article and Find Full Text PDFOphthalmic drug effects on the amyloidogenesis of a transforming growth factor β-induced protein (TGFBIp) peptide fragment.
Exp Eye Res
July 2024
Department of Ophthalmology, En Chu Kong Hospital, New Taipei City, 237, Taiwan. Electronic address:
Drugs that can treat one disease may either be detrimental or beneficial toward another due to possible cross-interactions. Therefore, care in choosing a suitable drug for patients with multiple diseases is crucial in successful patient management. This study explores several currently available ophthalmic drugs used to treat common ocular diseases to understand how they can affect the amyloidogenesis of a transforming growth factor β-induced protein (TGFBIp) peptide fragment found in abundance in the corneal protein aggregation deposits of lattice corneal dystrophy (LCD) patients.
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