AI Article Synopsis
- - Bisphenol A (BPA) is a common industrial chemical found in various products like packaging, CDs, and contact lenses, but its effects on human health, particularly on bone marrow cells, are not fully understood.
- - An experiment evaluated the impact of two BPA doses (0.05 mg/kg and 0.5 mg/kg) on erythroblastic cell lines in porcine bone marrow, assessing the number of cells before and after BPA exposure.
- - Results showed decreased production of erythroblastic cells and signs of anemia in both dosage groups, indicating that both high and low doses of BPA negatively affect blood cell production.
Article Abstract
Introduction: Bisphenol A (BPA) is a substance widely used in industry for the production of polycarbonates and epoxy resins used in packaging and containers for beverages, contact lenses, compact discs (CDs), window panes, and many other elements. This compound belongs to the group of polyphenols and xenoestrogens commonly found in the human environment. What we know about BPA is still insufficient to enable us to protect our health against its adverse effects, and current knowledge of the influence of BPA on erythroblastic cell lines in bone marrow is rather fragmentary. The aim of the experiment was to assess the effect of two doses of BPA (0.05 mg/kg and 0.5 mg/kg b.w. per day) on myeloid haematopoiesis.
Material And Methods: During this experiment, the number of all types of cells in the erythroblastic cell line was evaluated in porcine bone marrow before and after BPA administration.
Results: The obtained results clearly indicate changes in haematopoietic activity of the bone marrow, which was demonstrated by a decrease in erythroblastic cell line production in both experimental groups. The haematological effects of the bone marrow changes were anaemia, caused by a number of erythrocytes which was depressed due to their immaturity, and a significant decrease in mean cellular volume in both groups.
Conclusion: The harmful effect of high and low doses of BPA on haematopoietic processes was proved.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364150 | PMC |
| http://dx.doi.org/10.2478/jvetres-2018-0068 | DOI Listing |
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