AI Article Synopsis
- Iron and molybdenum are crucial trace elements that support enzyme function, cell growth, and DNA metabolism in cells.
- In experiments, BALB/3T3 and HepG2 cells were treated with varying concentrations of iron chloride and molybdenum trioxide to assess their effects on cell viability.
- The results showed that both trace elements reduced cell viability in a dose-dependent manner, with an even stronger decrease when used in combination, indicating a synergistic effect.
Article Abstract
Introduction: Iron and molybdenum are essential trace elements for cell metabolism. They are involved in maintaining proper functions of enzymes, cell proliferation, and metabolism of DNA.
Material And Methods: BALB/3T3 and HepG2 cells were incubated with iron chloride or molybdenum trioxide at concentrations from 100 to 1,400 μM. The cells were also incubated in mixtures of iron chloride at 200 μM plus molybdenum trioxide at 1,000 μM or iron chloride at 1,000 μM plus molybdenum trioxide at 200 μM. Cell viability was determined with MTT reduction, LHD release, and NRU tests.
Results: A decrease in cell viability was observed after incubating both cell lines with iron chloride or molybdenum trioxide. In cells incubated with mixtures of these trace elements, a decrease in cell viability was observed, assessed by all the used assays.
Conclusion: Iron (III) and molybdenum (III) decrease cell viability in normal and cancer cells. A synergistic effect of the mixture of these elements was observed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364151 | PMC |
| http://dx.doi.org/10.2478/jvetres-2018-0066 | DOI Listing |
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