AI Article Synopsis
- The study investigates the impact of antihypertensive therapy, particularly angiotensin system inhibitors (ASI), on the effectiveness of bevacizumab in patients with recurrent glioblastoma.
- Patients who began ASI after starting bevacizumab showed better progression-free survival and overall survival compared to those who did not.
- Additionally, using calcium antagonists while on bevacizumab therapy was linked to significantly improved overall survival rates in these patients.
Article Abstract
Purpose: Antihypertensive therapy may improve bevacizumab efficacy in cancer patients. We examined efficacy and toxicity of angiotensin system inhibitors (ASI) and other antihypertensive drugs in bevacizumab treated recurrent glioblastoma patients.
Methods: We retrospectively combined a national prescription registry with a clinical database with recurrent glioblastoma patients (n = 243).
Results: Patients who initiated ASI after bevacizumab (n = 26) showed a tendency towards improved progression-free survival and overall survival (OS) with hazard rate (HR) reductions (HR = 0.70 and HR = 0.79, respectively). Calcium antagonists during bevacizumab therapy significantly improved OS (HR = 0.57).
Conclusions: Overall the study supports a potential beneficial effect of antihypertensive treatment on prognosis of bevacizumab treated glioblastoma patients.
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| http://dx.doi.org/10.1080/07357907.2018.1544639 | DOI Listing |
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