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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360965 | PMC |
| http://dx.doi.org/10.1590/abd1806-4841.20198086 | DOI Listing |
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Luz de Wood en dermatosis inflamatorias, autoinmunes, infecciones y cáncer cutáneo.
Actas Dermosifiliogr
December 2024
Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, España; Servicio de Dermatología, Hospital de Figueres, Fundació Salut Empordà, España. Electronic address:
Wood's light (WL) is a useful, economical and easy-to-learn diagnostic tool. Despite its advantages, the use of LW among dermatologists is limited. In porokeratosis, the "diamond necklace" sign has been described, corresponding to the white fluorescence of the hyperkeratotic scale.
View Article and Find Full Text PDFTh Pathways in Immune-Mediated Skin Disorders: A Guide for Strategic Treatment Decisions.
Immune Netw
October 2024
Department of Dermatology, Ghent University Hospital, 9000 Ghent, Belgium.
In recent years, there have been significant breakthroughs in the identification of immunological components of skin diseases and in the development of immunomodulatory drugs. Novel therapies create exciting prospects for personalized care. This article provides an overview of the role played by Th1, Th2, Th17, and follicular Th pathways in the most common skin diseases.
View Article and Find Full Text PDFVariable clinical presentation of hypomorphic DCLRE1C deficiency from childhood to adulthood.
Pediatr Allergy Immunol
October 2024
Division of Pediatric Immunology and Allergy, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Article Synopsis
- The study focuses on long-term follow-up of 18 pediatric and adult patients with hypomorphic DCLRE1C mutations diagnosed with leaky severe combined immunodeficiency (SCID).
- Common clinical manifestations included recurrent infections, skin issues, autoimmune diseases, and malignancy, with a significant number of patients showing low immunoglobulin levels and T/B-cell lymphopenia.
- Findings suggested a dominant Th1 immune response, with elevated IFN-γ and T cells contributing to chronic inflammation and autoimmunity, emphasizing the need for ongoing patient monitoring post-hematopoietic stem cell transplantation (HSCT).
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Wood's Light in Inflammatory And Autoimmune Dermatoses, Infections and Skin Cancer.
Actas Dermosifiliogr
September 2024
Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España; Servicio de Dermatología, Hospital de Figueres, Fundació Salut Empordà, Figures, Girona, España. Electronic address:
Article Synopsis
- Wood's light (WL) is an effective and inexpensive diagnostic tool, but its usage is not very common among dermatologists.
- In conditions like porokeratosis and various pigmentary disorders, WL shows specific fluorescence patterns that help in diagnosis, such as the "diamond necklace" sign for porokeratosis and bluish fluorescence for vitiligo.
- WL is also valuable in identifying skin infections with distinct fluorescence colors, and it aids in determining surgical margins for certain skin cancers, although results can vary.
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