AI Article Synopsis
- A cross-sectional study was carried out at the Central Military Hospital in Lima, Peru, from January to September 2016, focusing on Pseudomonas aeruginosa isolates with reduced sensitivity to carbapenems and resistance to ceftazidime.
- Out of 76 analyzed isolates, 31.6% tested positive for metallo-β-lactamases (MBL) through phenotypic methods, and all were genetically confirmed.
- The blaIMP gene was found in 95.8% of the positive cases, while only 4.2% had the blaVIM gene, with no isolates containing the blaNDM gene, indicating blaIMP as the most common gene in these clinical isolates.
Article Abstract
hat codify metallo-β-lactamases (MBL) in clinical isolates of Pseudomona aeruginosa (P. aeruginosa), a cross-sectional study was conducted in the Central Military Hospital (HMC) of Lima, Peru, between January and September, 2016. Seventy-six (76) isolates of P. aeruginosa with diminished sensitivity to carbapenemes and resistant to ceftazidime were analyzed. The phenotype detection of MBL was made by double disc synergy between imipenem and meropenem versus ethylenediaminetetraacetic acid (EDTA), and the identification of the genes was performed by polymerase chain reaction. Of the 76 isolates, 24 (31.6%) were positive for MBL by the phenotype method, genetically confirming all. The blaIMP gene was found in 23/24 (95.8%) and blaVIM in 1/24 (4.2%). No isolate had blaNDM. The blaIMP gene turned out to be the most frequent among clinical isolates of P. aeruginosa not sensitive to carbapenemics at this Hospital.
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| http://dx.doi.org/10.17843/rpmesp.2018.354.3755 | DOI Listing |
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