Two new lignans, named (7R, 8S)-balanophonin (1) and (7R, 8S)-tomentosanan A (2), together with eight known lignans, burselignan (3), (+)-isolariciresinol (4), (+)-lyoniresinol (5), 5-methoxy-(+)-isolariciresinol (6), (-)-syringaresinol (7), (+)-epipinoresinol (8), (-)-(7'S, 8S, 8'R)-4,4'-dihydroxy-3, 3', 5, 5'-. tetramethoxy-7', 9-epoxy-lignan-9'-ol-7-one (9), and (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (10) were isolated from the whole plants of Hedyotis uncinella Hook. et Am. Structures of these compounds were elucidated through 1H NMR, "C NMR, 2D NMR, ESI-MS and CD data.
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J Ethnopharmacol
January 2025
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China. Electronic address:
Ethnopharmacological Relevance: Changyanning tablets (CYN) are a marketed traditional Chinese medicine composed of Diijincao (Euphorbia humifusa Willd.), Jinmaoercao (Hedyotis chrysotricha (Palib.) Merr.
View Article and Find Full Text PDFMolecules
January 2025
Graduate School of Biotechnology, Kyung Hee University, Yongin-si 17104, Republic of Korea.
The decline in autophagy disrupts homeostasis in skin cells, leading to oxidative stress, energy deficiency, and inflammation-all key contributors to skin photoaging. Consequently, activating autophagy has become a focal strategy for delaying skin photoaging. Natural plants are rich in functional molecules and widely used in the development of anti-photoaging cosmetics.
View Article and Find Full Text PDFInt Immunopharmacol
February 2025
Department of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong New Area, Shanghai 200127, China. Electronic address:
Hedyotis diffusa Willd. (HDW), a traditional Chinese medicinal plant, exhibits a variety of pharmacological effects and has anticancer potential for a wide range of cancer types; Ferroptosis is a non-apoptosis-regulated cell death induced by iron accumulation and subsequent lipid peroxidation; and there is currently an increasing interest in the therapeutic role of ferroptosis in cancer. However, the effects of HDW on bladder cancer and its underlying molecular mechanisms remain largely unknown.
View Article and Find Full Text PDFJ Fluoresc
January 2025
Chongqing College of Mobile Communication, Chongqing, 401520, China.
In this study, a simple and efficient method for synthesizing nitrogen-doped carbon quantum dots (N-CQDs) has been developed through a one-step hydrothermal process using hedyotis diffusa willd. The morphology, chemical composition, and optical properties of the resulting N-CQDs were thoroughly characterized. The synthesized N-CQDs exhibited a spherical shape with an average particle size of 4.
View Article and Find Full Text PDFJ Ovarian Res
December 2024
Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, 116044, China.
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