Scientific rationale are given for methodological approaches promoting improved reproducibility of 24-hour ECG monitoring data, for the method to be used repeatedly in assessing patient's condition. Repeated 24-hour-ECG monitoring in identical motor conditions (a standard mobility regimen) has been shown to improve considerably the reproducibility of its results. Criteria for the efficiency of antianginal therapy in patients with angina of the 2nd and 3d functional classes, as evidenced by 24-hour ECG monitoring, have been developed and substantiated. They are a drop in the number of ST depression episodes (by 3 and more) and in the total depth of depression (by 50% and more). The sensitivity of the assessment of each of the two indicators of myocardial ischemia or their combination was 70%, and the specificity was 77.8% and 88.9%, respectively.
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BMC Cardiovasc Disord
December 2024
Department of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Background: Numerous studies have demonstrated the significance of trimethylamine-N-oxide (TMAO) in the progression of atrial fibrillation (AF). However, the association between TMAO and AF recurrence (RAF) post-catheter ablation is not yet fully understood. This study aims to elucidate the predictive capability of pre-procedural TMAO levels in determining RAF following catheter ablation (CA).
View Article and Find Full Text PDFSci Rep
December 2024
Department of Internal Medicine I, TUM University Hospital, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
In contemporary healthcare, effective risk stratification in the general population is vital amidst rising chronic disease rates and an ageing demographic. Deceleration Capacity of the heart rate (DC), derived from 24-hour Holter electrocardiograms, holds promise in risk stratification for cardiac patients. However, the potential of short-term electrocardiograms of five minutes duration for population screening has not been fully explored.
View Article and Find Full Text PDFCirc Arrhythm Electrophysiol
December 2024
Jessa Ziekenhuis, Hasselt, Belgium (T.P., P.K., N.A., J.V.).
Background: Pulsed field ablation (PFA) is a promising treatment for atrial fibrillation. We report 1-year freedom from atrial arrhythmia outcomes using monopolar PFA delivered through 3 commercial, contact force-sensing focal catheters.
Methods: ECLIPSE AF (NCT04523545) was a prospective, single-arm, multicenter study evaluating acute and chronic safety and performance using the CENTAURI system to deliver focal PFA with TactiCath SE, StablePoint, and ThermoCool ST.
Neurology
January 2025
From the Neurovascular Research Group (I.F.-P., M.V.-P., L.R.-Á., E.G.S., A.O., E.C.-G., A.R.-C., A.S.-P., A.M.-G., J.J.-B., J.J.-C.), Hospital del Mar Research Institute; Neurology Department (I.F.-P., E.G.S., A.O., E.C.-G., A.R.-C., A.S.-P., A.M.-G., J.J.-C.), Hospital Del Mar; Faculty of Medicine and Life Sciences (E.G.S., A.O., E.C.-G., A.R.-C., J.J.-C.), Universitat Pompeu Fabra, Barcelona, Spain; Department of Psychiatry (C.S.-T.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (F.F.P.), Arnau de Vilanova Hospital, Lleida; Clinical Neurosciences Group (F.F.P., G.A.), Biomedical Research Institute of Lleida, University of Lleida; Neurobiology Laboratory (S.T., G.C., C.V.-B.), Neurology Department, Son Espases University Hospital, Health Research Institute of Balearic Islands; Department of Biology (G.C., C.V.-B.), Universitat de les Illes Balears, Palma de Mallorca; Department of Neurology (T.S.), and Research Unit (G.S.-H.), Albacete University Hospital Complex; and Center for Cooperative Research in Biosciences (U.L.), Basque Research and Technology Alliance, Bizkaia Technology Park, Derio, Spain.
Background And Objectives: Post-ischemic stroke (IS) outcomes vary widely among individuals, independently of clinical factors. This variability could be related to epigenetic mechanisms that regulate biological processes involved in recovery after ischemia. While several microRNAs (miRNAs) and their target genes are implicated in the pathophysiology of IS, their role in functional outcomes remains unclear.
View Article and Find Full Text PDFCureus
November 2024
Internal Medicine, University Hospitals Sussex NHS Foundation Trust, St Richard's Hospital, Chichester, GBR.
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