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Absence of sex differences in diabetes-induced suppression of KNDy neurons in rats.
J Endocrinol
December 2024
Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Diabetes mellitus disturbs kisspeptin-neurokinin B-dynorphin A (KNDy) neurons in the arcuate nucleus (ARC), which regulate pulsatile luteinizing hormone (LH) secretion in both sexes. However, it remains unclear whether a sex-specific association with the negative effects of diabetes on KNDy neurons exists. Therefore, we examined mRNA expression in KNDy neurons of diabetic male and female rats 7 weeks after streptozotocin (STZ) injection using histochemistry.
View Article and Find Full Text PDFPeripheral administration of a κ-opioid receptor agonist nalfurafine inactivates gonadotropin-releasing hormone pulse generator activity in goats.
Neurosci Lett
August 2024
Laboratory of Animal Production Science, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
Neurons co-expressing kisspeptin, neurokinin B, and dynorphin A (KNDy neurons), located in the arcuate nucleus (ARC) of the hypothalamus, are indicated to be the gonadotropin-releasing hormone (GnRH) pulse generator. Dynorphin A is reported to suppress GnRH pulse generator activity. Nalfurafine is a selective agonist of the κ-opioid receptor (KOR), a receptor for dynorphin A, clinically used as an anti-pruritic drug.
View Article and Find Full Text PDFEndogenous Opioids in Crohn's Disease.
Biomedicines
July 2023
Department of Clinical Biochemistry, Pediatric Institute, Faculty of Medicine, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Caring for patients with Crohn's disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy. Endogenous opioids are a group of low molecular weight chemical compounds with analgesic and anti-inflammatory properties.
View Article and Find Full Text PDFArticle Synopsis
- * NTX works by blocking mu-opioid receptors (MOP), and although its effects on these receptors are well understood, its interaction with kappa-opioid receptors (KOP) and how it influences addiction is less clear.
- * Research indicates that alcohol interacts with KOP in the plasma membrane, and NTX affects these interactions directly and indirectly, suggesting that its effectiveness in treating AUD may involve both MOP and KOP receptor activities.
The role of GnRH in Tibetan male sheep and goat reproduction.
Reprod Domest Anim
September 2023
Institute of Animal Science, Tibet Academy of Agricultural and Animal Husbandry Science, Lhasa, China.
The hypothalamic-pituitary-gonadal (HPG) axis connects the hypothalamus, pituitary gland, and gonads. The regulation of reproductive processes includes integrating various factors from structural functions and environmental conditions in the HPG axis, with the outcome indication of these processes being the pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. These factors include feed consumption and nutritional condition, sex steroids, season/photoperiod, pheromones, age, and stress.
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