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Differential serum levels of CACNA1C, circadian rhythm and stress response molecules in subjects with bipolar disorder: Associations with genetic and clinical factors.
J Affect Disord
December 2024
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA; Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:
Background: Many patients with bipolar disorder (BD) do not respond to or have difficulties tolerating lithium and/or other mood stabilizing agents. There is a need for personalized treatments based on biomarkers in guiding treatment options. The calcium voltage-gated channel CACNA1C is a promising candidate for developing personalized treatments.
View Article and Find Full Text PDFPolymorphisms in corticotrophin-releasing hormone-proopiomalanocortin (CRH-POMC) system genes: Neuroimmune contributions to psoriasis disease.
J Eur Acad Dermatol Venereol
October 2023
Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, Western Australia, Australia.
Background: Skin is a target organ and source of the corticotropin-releasing hormone-proopiomelanocortin (CRH-POMC) system, operating as a coordinator and executor of responses to stress. Environmental stress exacerbates and triggers inflammatory skin diseases through modifying the cellular components of the immune system supporting the importance of CRH-POMC system in the pathogenesis of psoriasis. The aim of this study was to analyse the association of CRH-POMC polymorphisms with psoriasis and evaluate transcript expression of lesional psoriatic and normal skin in RNA-seq data.
View Article and Find Full Text PDFThe Impact of Pharmacogenetics on Pharmacokinetics and Pharmacodynamics in Neonates and Infants: A Systematic Review.
Pharmgenomics Pers Med
June 2022
Department of Hospital Pharmacy, Erasmus MC, Rotterdam, the Netherlands.
In neonates, pharmacogenetics has an additional layer of complexity. This is because in addition to genetic variability in genes that code for proteins relevant to clinical pharmacology, there are rapidly maturational changes in these proteins. Consequently, pharmacotherapy in neonates has unique challenges.
View Article and Find Full Text PDFHypothalamic-pituitary-adrenal axis suppression in asthma: A glucocorticoid receptor polymorphism may protect.
Pediatr Allergy Immunol
February 2021
Paediatric Endocrine & Diabetes Unit, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Background: Asthmatic children on corticosteroids can develop hypothalamic-pituitary-adrenal axis suppression (HPAS). Single nucleotide polymorphisms (SNPs) rs242941 and rs1876828 of the corticotrophin-releasing hormone receptor 1 (CRHR1) gene were associated with lower stimulated cortisol (F) levels, whereas rs41423247 of the glucocorticoid receptor (NR3C1) gene was associated with higher basal F levels. The objective of the current study was to confirm whether these three SNPs are associated with HPAS in asthmatic children.
View Article and Find Full Text PDFGene-environment interactions between HPA-axis genes and childhood maltreatment in depression: a systematic review.
Acta Neuropsychiatr
January 2020
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Objective: Gene-environment (GxE) interactions may comprise an important part of the aetiology of depression, and childhood maltreatment (CM), a significant stressor, has consistently been linked to depression. Hence, in this systematic review, we aimed to investigate the interaction between hypothalamus-pituitary-adrenal axis (HPA-axis) genes and CM in depression.
Methods: We conducted a literature search using the Pubmed, Embase, and PsychINFO databases in adherence with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.
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