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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364011 | PMC |
| http://dx.doi.org/10.1128/JVI.01939-18 | DOI Listing |
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Design of a VLP-nanovehicle for CYP450 enzymatic activity delivery.
J Nanobiotechnology
October 2015
Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km 107 carretera Tijuana-Ensenada, 22860, Ensenada, Baja California, Mexico.
Background: The intracellular delivery of enzymes for therapeutic use has a promising future for the treatment of several diseases such as genetic disorders and cancer. Virus-like particles offer an interesting platform for enzymatic delivery to targeted cells because of their great cargo capacity and the enhancement of the biocatalyst stability towards several factors important in the practical application of these nanoparticles.
Results: We have designed a nano-bioreactor based on the encapsulation of a cytochrome P450 (CYP) inside the capsid derived from the bacteriophage P22.
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