AI Article Synopsis
- The study aimed to explore how cyclin D1 overexpression relates to important clinical factors in oral squamous cell carcinoma (OSCC), such as tumor grade and stage.
- Researchers conducted a retrospective analysis of 68 OSCC cases, using immunohistochemistry to examine cyclin D1 and ki-67 expression in tumor samples.
- Results showed that cyclin D1 overexpression occurs in approximately 28.7% of OSCC cases and is linked to poor prognostic indicators, including lower tumor differentiation, invasive nature, and higher cell proliferation rates.
Article Abstract
Objective: To evaluate the association of cyclin D1 overexpression with clinicopathological parameters classically considered of prognostic value in OSCC (T, N, M, clinical stage, degree of differentiation, invasive morphology and, cellular proliferation index).
Design: A retrospective immunohistochemical study was conducted of cyclin D1 and ki-67 expression in 68 OSCCs from 54 patients. Cases were scanned using a digital pathology system. The tumor expression of markers was assessed in four randomly selected fields (40x), and a semi-automatized count was conducted of cyclin D1-positive and -negative cells.
Results: Cyclin D1 overexpression was found in 28.7% of the cases of OSCC. It was significantly and positively associated with the following clinicopathological parameters: low tumor differentiation degree (p = 0.030), invasive morphology (p = 0.045), and proliferative phenotype according to tumor cell ki-67 expression (p = 0.018).
Conclusions: Cyclin D1 overexpression is an event of oral carcinogenesis associated with clinicopathological parameters classically associated with a poor prognosis in patients with OSCC.
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| http://dx.doi.org/10.1016/j.archoralbio.2019.01.018 | DOI Listing |
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