Connectomics, the reconstruction of neuronal wiring diagrams via electron microscopy, is bringing us closer to understanding how brains organize behavior. But high-resolution imaging of the brain can do more. A new study now provides insights into how neuronal circuits develop.
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Functional connectivity in resting-state networks relates to short-term global cognitive functioning in cardiac arrest survivors.
Hum Brain Mapp
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Donders Institute for Brain, Cognition and Behaviour, Centre of Expertise for Parkinson and Movement Disorders, Neurology Department, Radboud University Medical Centre, Nijmegen, The Netherlands.
Long-term cognitive impairment is common in cardiac arrest survivors. Screening to identify patients at risk is recommended. Functional magnetic resonance brain imaging (fMRI) holds potential to contribute to prediction of cognitive outcomes.
View Article and Find Full Text PDFWalking is a complex motor programme involving coordinated and distributed activity across the brain and the spinal cord. Halting appropriately at the correct time is a critical component of walking control. Despite progress in identifying neurons driving halting, the underlying neural circuit mechanisms responsible for overruling the competing walking state remain unclear.
View Article and Find Full Text PDFBiostasis: A Roadmap for Research in Preservation and Potential Revival of Humans.
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European Biostasis Foundation, 8197 Rafz, Switzerland.
Human biostasis, the preservation of a human when all other contemporary options for extension of quality life are exhausted, offers the speculative potential for survival via continuation of life in the future. While provably reversible preservation, also known as suspended animation, is not yet possible for humans, the primary justification for contemporary biostasis is the preservation of the brain, which is broadly considered the seat of memories, personality, and identity. By preserving the information contained within the brain's structures, it may be possible to resuscitate a healthy whole individual using advanced future technologies.
View Article and Find Full Text PDFIntraoperative awake language mapping correlates to preoperative connectomics imaging: An instructive case.
Clin Neurol Neurosurg
June 2023
Department of Neurological Surgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA. Electronic address:
Connectomics enables the study of structural-functional relationships in the brain, and machine learning technologies have enabled connectome maps to be developed for individual brain tumor patients. We report our experience using connectomics to plan and guide an awake craniotomy for a tumor impinging on the language area. Preoperative connectomics imaging demonstrated proximity of the tumor to parcellations of the language area.
View Article and Find Full Text PDFClinical factors associated with microstructural connectome related brain dysmaturation in term neonates with congenital heart disease.
Front Neurosci
November 2022
Department of Pediatric Radiology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Objective: Term congenital heart disease (CHD) neonates display abnormalities of brain structure and maturation, which are possibly related to underlying patient factors, abnormal physiology and perioperative insults. Our primary goal was to delineate associations between clinical factors and postnatal brain microstructure in term CHD neonates using diffusion tensor imaging (DTI) magnetic resonance (MR) acquisition combined with complementary data-driven connectome and seed-based tractography quantitative analyses. Our secondary goal was to delineate associations between mild dysplastic structural brain abnormalities and connectome and seed-base tractography quantitative analyses.
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