AI Article Synopsis
- The study developed a predictive in vitro method using a full-thickness skin model to assess how effective sunscreens are at providing photoprotection against UV radiation.
- Human fibroblasts and keratinocytes were used in the model, and exposure to daily UV radiation showed changes in gene expression related to oxidative stress, inflammation, and skin structure.
- The results indicated that the skin model effectively measured sunscreen efficacy, aligning with clinical protection factors and highlighting its potential for evaluating photoprotective products.
Article Abstract
Objective: This study aimed to establish a predictive in vitro method for assessing the photoprotective properties of sunscreens using a reconstructed full-thickness skin model.
Materials And Methods: A full-thickness skin model reconstructed with human fibroblasts and keratinocytes isolated from Chinese skin was exposed to daily UV radiation (DUVR). We examined the transcriptomic response, identifying genes for which expression was modulated by DUVR in a dose-dependent manner. We then validated the methodology for efficacy evaluation of different sunscreens formulas.
Results: The reconstructed skin model was histologically consistent with human skin, and upon DUVR exposure, the constituent fibroblasts and keratinocytes exhibited transcriptomic alterations in pathways associated with oxidative stress, inflammation and extracellular matrix remodelling. When used to evaluate sunscreen protection on the model, the observed level of protection from UV-induced gene expression was consistent with the corresponding protection factors determined clinically and allowed for statistical ranking of sunscreen efficacy.
Conclusions: Within this study we show that quantification of gene modulation within the reconstructed skin model is a biologically relevant approach with sensitivity and predictability to evaluate photoprotection products.
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| http://dx.doi.org/10.1111/ics.12518 | DOI Listing |
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