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mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii.
PLoS One
January 2025
Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasma gondii, an invasive intracellular apicomplexan protozoan parasite of global importance. T. gondii establishes a parasitophorous vacuole (PV) which shields the parasite from the host's intracellular defense mechanisms.
View Article and Find Full Text PDFUltrastructure expansion microscopy: Enlarging our perspective on apicomplexan cell division.
J Microsc
January 2025
Laboratory of Apicomplexan Biology, Institut Pasteur Montevideo, Montevideo, Uruguay.
Apicomplexans, a large phylum of protozoan intracellular parasites, well known for their ability to invade and proliferate within host cells, cause diseases with major health and economic impacts worldwide. These parasites are responsible for conditions such as malaria, cryptosporidiosis, and toxoplasmosis, which affect humans and other animals. Apicomplexans exhibit complex life cycles, marked by diverse modes of cell division, which are closely associated with their pathogenesis.
View Article and Find Full Text PDFImpact of Experimental Congenital Toxoplasmosis on the Thyroid Gland: Histopathological and Immunobiochemical Indices Assessment.
Acta Parasitol
January 2025
Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Purpose: The thyroid gland is one of the most vital endocrine organs. It is responsible for the synthesis and secretion of hormones principally triiodothyronine (T3) and thyroxine (T4). These hormones play a significant role in the functions and the metabolism of the body.
View Article and Find Full Text PDFDetection of Toxoplasma gondii in Brain Tissues of Pet Birds with Neurological Symptoms Using Loop-Mediated Isothermal Amplification (LAMP) and PCR.
Acta Parasitol
January 2025
Department of Microbiology & Immunology, Indiana University, School of Medicine, Indianapolis, IN, 46202, USA.
Background: This study seeks to close this divide by assessing the occurrence of Toxoplasma gondii (T. gondii) in the brain tissues of pet birds displaying neurological symptoms, utilizing Nested Polymerase Chain Reaction (PCR) and Loop-mediated Isothermal Amplification (LAMP) methods. Furthermore, it aims to evaluate and contrast the sensitivity and specificity of different diagnostic procedures.
View Article and Find Full Text PDFToxoplasma gondii Infection in the Male Reproductive System: A Systematic Review.
Acta Parasitol
January 2025
Reproduction Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia- UdeA, Medellín, Antioquia, Colombia.
Purpose: Toxoplasmosis is a worldwide widespread parasitic infection; it affects about 30% of the global population, either through acute toxoplasmosis or its sequels. Even though the male reproductive system is not the primary target for Toxoplasma gondii (T. gondii), studies have inquired into the possibility of presenting repercussions in this system directly or indirectly due to toxoplasmosis.
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