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Patterns of C1-Inhibitor Plasma Levels and Kinin-Kallikrein System Activation in Relation to COVID-19 Severity.
Life (Basel)
November 2024
Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy.
Background: Although more than four years have passed since the pandemic began, SARS-CoV-2 continues to be of concern. Therefore, research into the underlying mechanisms that contribute to the development of the disease, especially in more severe forms, remains a priority. Sustained activation of the complement (CS), contact (CAS), and fibrinolytic and kinin-kallikrein systems (KKS) has been shown to play a central role in the pathogenesis of the disease.
View Article and Find Full Text PDFHereditary angioedema (HAE) in children and adolescents: New treatment options.
Allergol Select
October 2024
Hannover Medical School (MHH), Department of Dermatology, Allergology and Venereology, Interdisciplinary Allergy Center of the MHH, Treatment Center for Hereditary Angioedema of the MHH, Hannover, Germany.
Article Synopsis
- Modern management of hereditary angioedema (HAE) emphasizes personalized treatment plans tailored to the needs of children and adolescents, as well as the severity of the disease.
- New medications have improved quality of life for HAE patients, but not all are approved for children, leading to ongoing research into alternative treatments such as those targeting bradykinin effects.
- Emerging options like oral medications, long-acting therapies, and potential gene therapy are being explored to better meet the care requirements for young patients with HAE type I and II.
Uncovering a novel SERPING1 pathogenic variant: insights into the aggregation of C1-INH in hereditary angioedema.
Orphanet J Rare Dis
September 2024
Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32 The First Ring Road West 2, Chengdu, Sichuan, 610072, China.
Article Synopsis
- Hereditary angioedema (HAE) is a rare genetic condition that causes recurrent swelling and can be life-threatening, with limited ways to predict or prevent attacks.
- A novel mutation in the SERPING1 gene was found in a Han family with HAE, leading to cellular dysfunction due to increased C1-INH levels and subsequent mitochondrial damage.
- Monitoring intracellular calcium levels may provide a new method for predicting HAE attacks, which could improve management strategies for the condition.
[Two pediatric hereditary angioedemathe families: case report and literature review].
Zhonghua Er Ke Za Zhi
September 2024
Department of Rheumatology and Immunology, Shenzhen Children's Hospital, Shenzhen 518038, China.
Article Synopsis
- The study looks at two families with a condition called hereditary angioedema, which causes swelling in different body parts, especially in children.
- One girl, age 12, had ongoing stomach pain and was found to have a genetic change related to her condition, while another girl, age 17, had swelling in her limbs and was also diagnosed with a different type of hereditary angioedema.
- Researchers reviewed a lot of information about this condition in kids and found that it can be inherited and often starts showing symptoms between ages 1 and 15.
sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID.
iScience
July 2024
Research and Development Department, Hycult Biotech, Uden, the Netherlands.
Biomarkers for monitoring COVID-19 disease course are lacking. Study aim was to identify biomarkers associated with disease severity, survival, long-term outcome, and Long COVID. As excessive macrophages activation is a hallmark of COVID-19 and complement activation is key in this, we selected the following proteins involved in these processes: PTX3, C1q, C1-INH, C1s/C1-INH, and sMR.
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