Base-catalyzed annulation reactions of 5,6-dihydro-2(1)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized -perhydroisoquinolin-1-ones.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385050 | PMC |
| http://dx.doi.org/10.3390/molecules24030557 | DOI Listing |
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