Two new alkaloids indolepyrazines A () and B () were isolated from the marine-derived sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation. Indolepyrazine A represents the first example of alkaloids with an indole-pyrazine-oxindole skeleton. Both and showed antimicrobial activities against methicillin-resistant , , and with minimum inhibitory concentration (MIC) values of 12 μg/mL, 8⁻10 μg/mL, and 12⁻14 μg/mL, respectively.
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