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Mycosis fungoides (MF) is a neoplasm of the immune system. It is a cutaneous lymphoma originating in the peripheral epidermotropic T-cells, specifically the memory T-cells (CD45RO+). The etiology of MF is indefinite, but various factors, such as genetic and epigenetic abnormalities, environmental and occupational exposure to chemicals, infections, and cytokines (interleukin [IL]-2, IL-4, etc.

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Oral lichenoid lesions in two snuff users with contact allergy to carvone.

Contact Dermatitis

January 2024

Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmo, Sweden.

Article Synopsis
  • A study was conducted to examine if mint-flavoured snuff is linked to contact allergy from carvone, which has been noted in patients with oral lichenoid lesions (OLL).
  • Two patients with OLL were found to be allergic to carvone through patch testing, and they had been using mint-flavoured snuff for years; carvone was also detected in their snuff samples.
  • After being advised to stop using mint-flavoured products, the patients showed significant improvement in their oral symptoms within three months, suggesting that mint-flavouring can worsen OLL.
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Allergic contact dermatitis (ACD) is a common inflammatory skin disease that, especially when the condition becomes chronic, has a high impact on the quality of life and represents a significant disease burden. ACD represents a type IV delayed-type hypersensitivity reaction that is triggered by contact with an allergen in previously sensitized individuals through the activation of allergen-specific T cells. In the acute phase, it is characterized by eczematous dermatitis, which presents with erythema, edema, vesicles, scaling, and intense itch.

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Background: The mint flavour carvone (l-carvone) is considered a weak contact allergen. However, contact allergy to carvone is more prevalent in patients with oral lichen planus or oral lichenoid lesions (OLP/OLL).

Objective: Our aim was to investigate how carvone affects sensitized individuals through a use test with toothpaste containing carvone.

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