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| http://dx.doi.org/10.1002/mdc3.12467 | DOI Listing |
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Clinical aspects of neuromuscular transmission disorders.
Acta Neurol Scand Suppl
June 2006
Neuroscience Department, Catholic University, Roma, Italy.
Autoimmune disorders of neuromuscular transmission are caused by antibodies (abs) directed against membrane proteins at the motor end-plate. Myasthenia gravis (MG) is due, in most cases, to abs against the nicotinic acetylcholine receptor (AChR). Anti-AChR-positive MG actually includes different disease entities: weakness can be confined to extrinsic ocular muscles or can be generalized; patients with generalized MG (G-MG) can be subdivided on the basis of age of onset, HLA association and thymic pathology.
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