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| http://dx.doi.org/10.1002/mdc3.12069 | DOI Listing |
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Ferroptosis promotes valproate-induced liver steatosis in vitro and in vivo.
Food Chem Toxicol
October 2024
School of Life Science, Jilin University, Changchun, 130012, China. Electronic address:
Article Synopsis
- * The study found that VPA increases ferroptosis in mouse livers by raising levels of ferrous iron, disrupting the balance of antioxidants, and promoting the generation of lipid peroxides, resulting in greater liver fat accumulation.
- * Co-treating with an iron-chelating drug and a ferroptosis inhibitor significantly reversed the negative effects of VPA, suggesting that targeting ferroptosis could be a potential treatment for liver problems in patients using
Biochemical and Histological Effects of Extract against Valproate-Induced Kidney Damage.
J Med Food
June 2024
Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, Istanbul, Türkiye.
Valproic acid is an effective treatment for generalized seizure and related neurological defects. Despite its efficacy and acceptability, its use is associated with adverse drug effects. leaves are rich in phytochemical and nutritional components.
View Article and Find Full Text PDFSodium valproate-induced nocturnal enuresis in epilepsy: Three case reports and a review of the literature.
Front Neurol
March 2023
Department of Emergency, Xiangya Hospital, Central South University, Changsha, China.
Background: Enuresis is an uncommon adverse effect of sodium valproate therapy that is unknown to most clinicians. This study provides an overview of the literature on enuresis associated with sodium valproate therapy, discussing the clinical manifestations and possible mechanisms of this side effect.
Methods: We reported three cases of enuresis induced by sodium valproate and reviewed the published enuresis cases associated with sodium valproate therapy retrieved from databases.
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability.
Brain
November 2022
Department of Brain Sciences, Imperial College London, London, UK.
Prenatal exposure to the anti-seizure medication sodium valproate (VPA) is associated with an increased risk of adverse postnatal neurodevelopmental outcomes, including lowered intellectual ability, autism spectrum disorder and attention-deficit hyperactivity disorder. In this study, we aimed to clarify the molecular mechanisms underpinning the neurodevelopmental consequences of gestational VPA exposure using integrative genomics. We assessed the effect of gestational VPA on foetal brain gene expression using a validated rat model of valproate teratogenicity that mimics the human scenario of chronic oral valproate treatment during pregnancy at doses that are therapeutically relevant to the treatment of epilepsy.
View Article and Find Full Text PDFTwo-step treatment of a giant skull vault hemangioma: A rare case report and literature review.
Neurocirugia (Astur : Engl Ed)
May 2022
Department of Neurosurgery, 401 General Military Hospital of Athens, Kanellopoulou & Mesogeion Avenue, 11527 Athens, Greece.
Skull vault hemangiomas are benign vascular tumours of the calvaria that are usually asymptomatic or present as firm, painless lumps. We present a case of a 59-year-old female with a giant intraosseous calvarial hemangioma that was admitted in our department with a palpable mass over the left frontoparietal region, personality changes and impaired emotional and cognitive functions. The patient was treated with a two-step approach involving endovascular and surgical treatment, and suffered two rare, but recognized complications, a contrecoup intracerebral haemorrhage and valproate-induced stupor and parkinsonism.
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