A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session2a6sgaair60krtch056ghtsemngb4h9h): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 197

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3145
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A fast and reliable test for parallelism in bioassay. | LitMetric

A fast and reliable test for parallelism in bioassay.

J Biopharm Stat

Department of Statistical Sciences, MedImmune LLC, Gaithersburg, Maryland, USA.

Published: October 2020

Parallelism in bioassay is a synonym of similarity between two concentration-response curves. Before the determination of relative potency in bioassays, it is necessary to test for and claim parallelism between the pair of concentration-response curves of reference standard and test sample. Methods for parallelism testing include -value-based significance tests and interval-based equivalence tests. Most of the latter approaches make statistical inference about the equivalence of parameters of the concentration-response curve models. An apparent drawback of such methods is that equivalence in model parameters does not guarantee similarity between the reference and test sample. In contrast, a Bayesian method was recently proposed that directly tests the parallelism hypothesis that the concentration-response curve of the test sample is a horizontal shift of that of the reference. In other words, the testing sample is a dilution or concentration of the reference standard. The Bayesian approach is shown to protect against type I error and provides sufficient statistical power for parallelism testing. In practice, however, it is challenging to implement the method as it requires both specialized Bayesian software and a relatively long run time. In this paper, we propose a frequentist version of the test with split-second run time. The empirical properties of the frequentist parallelism test method are evaluated and compared with the original Bayesian method. It is demonstrated that the frequentist method is both fast and reliable for parallelism testing for a variety of concentration-response models.

Download full-text PDF

Source
http://dx.doi.org/10.1080/10543406.2019.1572615DOI Listing

Publication Analysis

Top Keywords

test sample
12
parallelism testing
12
fast reliable
8
parallelism
8
parallelism bioassay
8
concentration-response curves
8
reference standard
8
concentration-response curve
8
bayesian method
8
test
7

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!