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http://dx.doi.org/10.1111/tops.12409 | DOI Listing |
Aust N Z J Obstet Gynaecol
December 2024
The Western Australian Centre for Health Research for Women and Babies, The University of Western Australia, Perth, Western Australia, Australia.
Surg Endosc
December 2024
General and Digestive Surgery Department, Hepato-Biliary and Pancreatic Surgery Unit, Valme University Hospital, Ctra. de Cádiz Km548.9. 41014, Seville, Spain.
Introduction: Choledocholithiasis is a common clinical condition that may present with severe complications such as acute cholecystitis or cholangitis, requiring treatment on an emergency setting. This situation is frequently managed following an endoscopic approach by ERCP. However, access to emergent endoscopic biliary decompression is lacking in most centers.
View Article and Find Full Text PDFNat Commun
December 2024
The SKI Stem Cell Research Facility, The Center for Stem Cell Biology and Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY, USA.
Prime editing (PE) allows for precise genome editing in human pluripotent stem cells (hPSCs), such as introducing single nucleotide modifications, small insertions or deletions at a specific genomic locus. Here, we systematically compare a panel of prime editing conditions in hPSCs and generate a potent prime editor, "PE-Plus", through co-inhibition of mismatch repair and p53-mediated cellular stress responses. We further establish an inducible prime editing platform in hPSCs by incorporating the PE-Plus into a safe-harbor locus and demonstrated temporal control of precise editing in both hPSCs and differentiated cells.
View Article and Find Full Text PDFBMC Womens Health
December 2024
Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Introduction: IUDs are effective, reversible and safe methods of contraception. The mechanism of action of IUDs as a group is inducing endometrial atrophy, apoptosis, altering tubal motility; preventing sperm permeability, fertilization, and implantation. Complications of IUD include menstrual disturbance, pelvic pain, and increased risk of ectopic pregnancy with contraceptive failure, device expulsion, uterine perforation or transmural migration with misplacement of the device.
View Article and Find Full Text PDFPerspect Med Educ
December 2024
School of Health Professions Education (SHE), Faculty of Health, Medicine and Life sciences, Maastricht University, Maastricht, The Netherlands.
Introduction: Undergraduate healthcare students on placement abroad can experience challenges that affect their wellbeing, personal and professional development. These challenges may result in students taking a more peripheral role in workplace activities, which negatively impacts learning. We studied .
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