AI Article Synopsis
- The review focuses on new findings related to hypertension associated with autoimmune diseases like lupus and rheumatoid arthritis, highlighting a higher risk for cardiovascular issues.
- Recent studies suggest that genetic, environmental, hormonal, and metabolic factors enhance the risk of hypertension due to chronic inflammation linked to autoimmune diseases.
- The article emphasizes the role of autoantibodies, immune dysfunction, and factors like sex hormones and oxidative stress in driving hypertension and vascular issues in these patients.
Article Abstract
Purpose Of Review: To highlight important new findings on the topic of autoimmune disease-associated hypertension.
Recent Findings: Autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis are associated with an increased risk for hypertension and cardiovascular disease. A complex interaction among genetic, environmental, hormonal, and metabolic factors contribute to autoimmune disease susceptibility while promoting chronic inflammation that can lead to alterations in blood pressure. Recent studies emphasize an important mechanistic role for autoantibodies in autoimmune disease-associated hypertension. Moving forward, understanding how sex hormones, neutrophils, and mitochondrial dysfunction contribute to hypertension in autoimmune disease will be important. This review examines the prevalent hypertension in autoimmune disease with a focus on the impact of immune system dysfunction on vascular dysfunction and renal hemodynamics as primary mediators with oxidative stress as a main contributor.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394456 | PMC |
| http://dx.doi.org/10.1007/s11906-019-0914-2 | DOI Listing |
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