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Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.
NPJ Regen Med
January 2025
Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, USA.
Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity. Calcium is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. Here we show a robust pathway for new calcium signaling-based cardiac regenerative strategies.
View Article and Find Full Text PDFA co-designed health education model to improve outcomes for children with emotional and behavioural difficulties: a study of acceptability, feasibility and impacts.
Arch Dis Child
January 2025
Health Services Research Unit, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Objective: To assess the acceptability and impacts of a co-designed health education model aiming to improve outcomes for children with emotional and behavioural difficulties.
Design: Qualitative focus group study.
Setting: Six primary schools from metropolitan and rural settings in the state of Victoria, Australia.
Ethical Food Consumption in the Digital Age: Consumer Attitudes Towards Digitally Monitored Animal Welfare in Pork Products.
Appetite
January 2025
Faculty of Business and Law, Curtin University, Perth, Western Australia, Australia.
Climate change is an emerging global reality with widespread effects on ecosystems and human communities. However, its significant impact on livestock animals often goes underdiscussed as more focus is given to impact of livestock production on climate change. Implementing high-welfare systems, such as digital monitoring of animals, can help mitigate climate-related challenges by reducing temperature fluctuations and controlling disease spread.
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