Objective: To analyze the blood type of a family with B(A) blood type.
Methods: The serological blood type of the family was determined by routine tube method. Exons 6 and 7 of the ABO gene were amplified by PCR and subjected to Sanger sequencing.
Results: Serological testing of the proband and her elder son showed a discrepancy which was initially identified as B(A) subtype. Her husband and second son were identified as blood type O. Sequencing of the proband and her elder son has identified an O allele and a 640A>G mutation compared with the B gene. Her husband and second son possessed the same genotype of O/O.
Conclusion: The 640A>G mutation of ABO gene probably underlies the B(A) subtype.
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| http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2019.02.018 | DOI Listing |
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