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Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with based on single-cell sequencing.
Open Med (Wars)
January 2025
Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University, 183 West Zhongshan Road, Guangzhou, China.
Chromoblastomycosis (CBM) is a chronic neglected fungal disease that causes serious damage to the physical and mental health of patients. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has garnered significant attention in the recent era for the treatment of CBM and has exhibited promising effects in several clinical case reports. We established a mice footpad infection model with and analyzed the impact of PDT treatment on the immune response of macrophages using single-cell sequencing.
View Article and Find Full Text PDFSuccessful Treatment of Chromoblastomycosis caused by Cladophialophora carrionii with Itraconazole: Clinicopathology, Susceptibility, and Molecular Identification of a Case in Northern China.
Am J Trop Med Hyg
December 2024
Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
Chromoblastomycosis (CBM), a prevalent subcutaneous mycosis in tropical and subtropical regions caused by dematiaceous fungi, often presents as refractory lesions. This case report details a 63-year-old woman from Tianjin, China, with CBM caused by Cladophialophora carrionii after plant trauma. Successful treatment with itraconazole was performed.
View Article and Find Full Text PDFEffects of ALA-PDT on the murine footpad model of Fonsecaea monophora infection and its related mechanisms in vivo.
Photodiagnosis Photodyn Ther
December 2024
Department of Dermatology and Venereology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, PR China. Electronic address:
Background: 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has received growing attention for treating chromoblastomycosis (CBM) and has shown efficacy in a handful of clinical case reports. However, there is insufficient information regarding the effects of ALA-PDT on Fonsecaea monophora in mouse infection model and the related mechanisms. This study investigated these issues in vivo.
View Article and Find Full Text PDFDeep Fungal Infections of Skin and Role of Histopathology in Diagnosis.
Indian J Dermatol
October 2024
Department of Dermatology, Institute of Child Health, Kolkata, India.
Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.
Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.
Treatment-Resistant Chromoblastomycosis Successfully Managed With Surgical Excision.
Cureus
November 2024
Dermatology, University of California Davis Medical Center, Sacramento, USA.
Chromoblastomycosis is an uncommon, chronic granulomatous fungal infection of the skin and subcutaneous tissue. Chromoblastomycosis is most commonly caused by the traumatic inoculation of dematiaceous (pigmented) fungi, most commonly species, species, and species. Chromoblastomycosis usually affects agricultural workers in tropical and subtropical climates.
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