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File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
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Message: Trying to access array offset on value of type null
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
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Message: Trying to access array offset on value of type null
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Severity: 8192
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Filename: models/Detail_model.php
Line Number: 71
Backtrace:
File: /var/www/html/application/models/Detail_model.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Severity: 8192
Message: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated
Filename: helpers/my_audit_helper.php
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Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Filename: controllers/Detail.php
Line Number: 256
Backtrace:
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Severity: Warning
Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
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Backtrace:
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/index.php
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Message: Trying to access array offset on value of type null
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Filename: controllers/Detail.php
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Message: Trying to access array offset on value of type null
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Message: Trying to access array offset on value of type null
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Backtrace:
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File: /var/www/html/index.php
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File: /var/www/html/application/helpers/my_audit_helper.php
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Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
File: /var/www/html/application/controllers/Detail.php
File: /var/www/html/application/controllers/Detail.php
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Translation of Human β-Actin mRNA is Regulated by mTOR Pathway. | LitMetric
The mammalian target of rapamycin (mTOR) kinase is a well-known master regulator of growth-dependent gene expression in higher eukaryotes. Translation regulation is an important function of the mTORC1 pathway that controls the synthesis of many ribosomal proteins and translation factors. Housekeeping genes such as () are widely used as negative control genes in studies of growth-dependent translation. Here we demonstrate that translation of both endogenous and reporter mRNA is inhibited in the presence of mTOR kinase inhibitor (Torin1) and under amino acid starvation. Notably, 5'UTR and promoter of are sufficient for the mTOR-dependent translational response, and the degree of mTOR-sensitivity of mRNA translation is cell type-dependent.
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