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Allergic Rhinitis and Its Associated Co-Morbidities Among Patients Attending the ENT Department at Kilimanjaro Christian Medical Center in Northern Tanzania: Cross-Sectional Study.
Immun Inflamm Dis
January 2025
Department of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Introduction: Allergic rhinitis is the specific inflammation against allergen by immune defense cells on the nasal mucosa, which can lead to chronic nasal symptoms such as sneezing, itching, runny nose, and nasal congestion. It is associated with high morbidity including sinusitis, asthma, otitis media, hypertrophied inferior turbinate, and nasal polyps. Despite its complications, it remains poorly recognized and tracked.
View Article and Find Full Text PDFRegulatory B-Cells Are Associated Negatively With Regulatory T-Cells and Positively With Cytokines in Peripheral Blood of Pregnant Women.
Am J Reprod Immunol
February 2025
Department of Anthropology, University of California, Los Angeles, California, USA.
Problem: Regulatory B-cells (Bregs, CD19CD24CD38) are a specialized B-cell subset that suppresses immune responses and potentially contribute to the maintenance of an immune-privileged environment for fetal development during pregnancy. However, little is known about the surrounding immunological environment of Bregs in gestational physiology. The relationship of regulatory T-cells (Tregs, CD4CD25CD127FoxP3) to Bregs in coordinating immunoregulation during pregnancy is unknown.
View Article and Find Full Text PDFEstimation of Diagnostic Test Accuracy Without Gold Standards.
Stat Med
February 2025
Department of Biostatistics and Beijing International Center for Mathematical Research, Peking University, Beijing, China.
The ideal evaluation of diagnostic test performance requires a reference test that is free of errors. However, for many diseases, obtaining such a "gold standard" reference is either impossible or prohibitively expensive. Estimating test accuracy in the absence of a gold standard is therefore a significant challenge.
View Article and Find Full Text PDFTesting One Primary and Two Secondary Endpoints in a Two-Stage Group Sequential Trial With Extensions.
Stat Med
February 2025
Villanova University, Villanova, Pennsylvania, USA.
We study the problem of testing multiple secondary endpoints conditional on a primary endpoint being significant in a two-stage group sequential procedure, focusing on two secondary endpoints. This extends our previous work with one secondary endpoint. The test for the secondary null hypotheses is a closed procedure.
View Article and Find Full Text PDFToward Equitable Access to Psychosocial Screening in Canada: Validation of the French-Canadian Psychosocial Assessment Tool.
Pediatr Blood Cancer
March 2025
Azrieli Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
Objective: The Psychosocial Assessment Tool (PAT) is a brief caregiver report, family-centered, psychosocial risk screening tool widely used in pediatrics and available in many languages. Although French is an official language of Canada, a French-Canadian version of the PAT has not yet been validated, which impedes access to this tool for family psychosocial screening. This study aimed to translate, adapt as necessary, and validate the French-Canadian version of the PAT.
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