AI Article Synopsis
- The 3-iodopropyl acetal moiety acts as a cleavable unit that, when exposed to acid, releases hydrogen iodide (HI) and acrolein.
- By incorporating this unit into linear and network polymers, a new type of macromolecule is created that degrades through a unique mechanism.
- This acid-responsive polymer exhibits an accelerated degradation rate and enhanced release of agents in a sigmoidal manner.
Article Abstract
We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p K ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives a class of macromolecules that undergo a new mechanism of degradation with an acid amplified, sigmoidal rate. This trigger-responsive self-amplified degradable polymer undergoes accelerated rate of degradation and agent release.
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| http://dx.doi.org/10.1021/jacs.8b07705 | DOI Listing |
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