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Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses.
Nutrients
December 2024
Department of Cardiology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
The relationship between folate concentrations and stroke risk remains unestablished, and the mediation effect of homocysteine (Hcy) and interaction effect of methylenetetrahydrofolate reductase () gene polymorphism has yet to be investigated. This cohort study involved 4903 subjects derived from a Chinese community population. The association between folate and first stroke was examined in Cox proportional hazard regression models.
View Article and Find Full Text PDFPreconceptional and Periconceptional Folic Acid Supplementation in the Visegrad Group Countries for the Prevention of Neural Tube Defects.
Nutrients
December 2024
2nd Department of Gynecology and Obstetrics, University Hospital Bratislava and Comenius University, 821 01 Bratislava, Slovakia.
Neural tube defects (NTDs) are malformations of the central nervous system that represent the second most common cause of congenital morbidity and mortality, following cardiovascular abnormalities. Maternal nutrition, particularly folic acid, a B vitamin, is crucial in the etiology of NTDs. FA plays a key role in DNA methylation, synthesis, and repair, acting as a cofactor in one-carbon transfer reactions essential for neural tube development.
View Article and Find Full Text PDFRisk Factors Related to Resting Metabolic Rate-Related Gene Variation in Children with Overweight/Obesity: 3-Year Panel Study.
Nutrients
December 2024
Department of Food & Nutrition & Research Institute of Obesity Sciences, Sungshin Women's University, Dobongro-76gagil-55, Kangbuk-ku, Seoul 01133, Republic of Korea.
Unlabelled: This study investigated how the gene variation related to RMR alteration affects risk factors of obese environments in children with obesity aged 8-9.
Methods: Over a three-year follow-up period, 63.3% of original students participated.
Genomic Insights into Host Susceptibility to Periprosthetic Joint Infections: A Comprehensive Literature Review.
Microorganisms
December 2024
Orthopedic Surgery Department, Cleveland Clinic, Weston, FL 33331, USA.
Periprosthetic joint infection (PJI) is a multifactorial disease, and the risk of contracting infection is determined by the complex interplays between environmental and host-related factors. While research has shown that certain individuals may have a genetic predisposition for PJI, the existing literature is scarce, and the heterogeneity in the assessed genes limits its clinical applicability. Our review on genetic susceptibility for PJI has the following two objectives: (1) Explore the potential risk of developing PJI based on specific genetic polymorphisms or allelic variations; and (2) Characterize the regulatory cascades involved in the risk of developing PJI.
View Article and Find Full Text PDFGene Polymorphisms and DNA Methylation in Idiopathic Spontaneous Preterm Birth.
Medicina (Kaunas)
December 2024
Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
: Preterm birth (PTB) is a complex condition with various contributing factors, including genetic and epigenetic influences such as DNA methylation. Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in DNA methylation and the remethylation of homocysteine. This study aimed to investigate the association between maternal MTHFR C677T and A1298C polymorphisms, LINE-1 DNA methylation levels, and the risk of idiopathic spontaneous preterm birth (SPTB) in Caucasian women from Croatia and Slovenia.
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