Aim: To experimentally define the optimum modes ofoperation ofthe nonspecific detector IBAC integrated with C100 sampler and BioCapture sampler in model experiments during the work in various environmental conditions and at dispersion of the biological aerosol.
Materials And Methods: The nonspecific detector IBAC with the C100 sampler and the BioCapture sampler were used for air-monitoring test on existence of pathogenic biological agents (PBA). For preparation of the bioaerosols the strain of Salmonella typhimurium 9640 and a bull seralbumin were used.
Results: It is experimentally established that programming of IBAC on turning on the bioalarm system when maintaining concentration of bioaerosol in air above threshold level during 10 sec. is optimum. Its sensitivity makes 1x10³ m.c./ml of aerosol at this mode. The possibility of operation of air-monitoring instrumentation in various environmental conditions inside and outside is shown.
Conclusion: As a result of the experi- ment the effectiveness of usage of the nonspecific detector IBAC with the C100 sampler and BioCapture sampler for air-monitoring on existence of PBA is proved. IBAC with C100 can be used as an inventory ofthe station ofair-monitoring during the public events, and BioCapture is suitable for equipment of the groups of epidemiological investigation.
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Acad Radiol
January 2025
Department of Radiology, Shengjing Hospital of China Medical University, China (Y.Y., T.W.). Electronic address:
Rationale And Objectives: Mixed ground-glass nodules (mGGNs) are highly malignant and common nonspecific lung imaging findings. This study aimed to explore whether combining quantitative and qualitative spectral dual-layer detector-based computed tomography (SDCT)-derived parameters with serological tumor abnormal proteins (TAPs) and thymidine kinase 1 (TK1) expression enhances invasive mGGN diagnostic efficacy and to develop a joint diagnostic model.
Materials And Methods: This prospective study included patients with mGGNs undergoing preoperative triple-phase contrast-enhanced SDCT with TAP and TK1 tests.
Mycobiology
October 2024
State Key Laboratory of Efficient Production of Forest Resources, School of Ecology and Nature Conservation, Beijing Forestry University, Beijing, China.
Owing to the production of lignin-modifying enzymes (LMEs), white-rot fungi (WRF) such as polypores are potent organisms in the biodegradation of xenobiotic pollutants. The nonspecific function of LMEs including laccase and manganese peroxidase (MnP), has enabled the use of WRF in biotechnological applications, particularly in bioremediation. In this study, 12 strains from nine white-rot basidiomycete genera viz.
View Article and Find Full Text PDFBiosens Bioelectron
February 2025
Department of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address:
SERS detects single molecules with exceptional sensitivity. To counter the issue of selectivity faced by point-of-care, herein, an externally applied electric field that allows electrical modulation and electromigrates unbound SERS tags without multiple washing steps is successfully developed and demonstrated to improve the biosensor's selectivity and sensitivity in multiplexed detection of cTnI, HDL, and LDL in human serum at a low LoD. Ultra-sensitive detectors can detect signals from non-specifically absorbed species, and these species can cover up overlapping analyte peaks, amplifying the effect of non-specific binding.
View Article and Find Full Text PDFCells
October 2024
Scientific Commercialization, Cytek Biosciences, Inc., 47215 Lakeview Boulevard, Fremont, CA 94538, USA.
Flow cytometry facilitates the detection of multiple cell parameters simultaneously with a high level of resolution and throughput, enabling in-depth immunological evaluations. High data resolution in flow cytometry depends on multiple factors, including the concentration of reagents used in the staining protocol, and reagent validation and titration should be the first step in any assay optimization. Titration is the process of finding the concentration of the reagent that best resolves a positive signal from the background, with the saturation of all binding sites, and minimal antibody excess.
View Article and Find Full Text PDFCompr Rev Food Sci Food Saf
November 2024
College of Food Science & Technology, Nanchang University, Nanchang, Jiangxi, P. R. China.
Accurate quantification of allergens in food is crucial for ensuring consumer safety. Pretreatment steps directly affect accuracy and efficiency of allergen quantification. We systematically reviewed the latest advances in pretreatment steps for antibody-based methods and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) protein quantification methods in food.
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